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Aeon is a leader in the field of pharmacogenomics testing and is pleased to offer our
pharmacogenomics diagnostic services. This genetic testing profile provides information on the
connection between a patient’s unique genetic makeup and their response to certain cardiology,
pain and psychiatry medications.

For example, certain genetic mutations cause either higher or lower rates of metabolism for
known drugs. Aeon’s Comprehensive PGX Profile also includes genetic-metabolic relationships
for antifungal, antiemetic, acid disorder, immunosupressant and urinary incontinence
medications. Risk factors for thrombophilia, hyperhomocysteinemia and dyslipidemia are also
tested. All pharmacogenetic patient samples are handled with the greatest care by highly trained
scientists in our state-of-the-art facility. Our detailed but easy to read reports will ensure you
treat your patients with the most up to date information. Trust Aeon for your pharmacogenomic
testing needs.

Our testing screens the following impacted medications, genes, and cardiology risk factors:
**Click on any of the potential drugs, genes tested, or conditions to learn more.**

Impacted Medications and Genes Tested

Drug Class Potentially Impacted Drugs Gene(s) Tested
ADHD Atomoxetine, Amphetamines,
Dexmethylphenidate,
Dextroamphetamine,
Lisdexamfetamine, Methylphenidate
CYP2D6, COMT
Alzheimer’s Disease Donepezil, Galantamine CYP2D6
Anitarrhythmics Flecainide, Propafenone, Mexiletine CYP2D6
Antidepressants, SSRIs/SNRI Citalopram, Escitalopram,
Desvenlafaxine, Duloxetine,
Mirtazapine, ParoxetineSertraline,
Venlafaxine
CYP2D6, CYP2C19
Antidepressants, Tricyclic Amitriptyline, Clomipramine,
Desipramine, Doxepin, Imipramine,
Nortriptyline, Trimipramine
CYP2D6, CYP2C19
Antidiabetics Glimepiride, GlipizideGlyburide,
Tolbutamide
CYP2C9
Antiemetics Ondansetron CYP2D6
Antiepileptic Phenytoin CYP2C9
Antihyperlipidemic Agents Atorvastatin, Fluvastatin, Lovastatin,
PravastatinPitavastatin, Simvastatin,
Rosuvastatin
SLCO1B1, CYP3A4, CYP2C9
Antihypertensives Carvedilol, Metoprolol, Irbesartan,
Nebivolol, Propanolol, Timolol
CYP2D6, CYP2C9
Antiplatelets-Anticoagulants Clopidogrel, Prasugrel, Ticagrelor,
Warfarin
CYP2C19, CYP2C9, VKORC1,
CYP3A5
Antipsychotics Aripiprazole, Haloperidol, Iloperidone,
Paliperidone, Perphenazine, Pimozide,
RisperidoneThioridazine
CYP2D6, CYP1A2
Anxiety/Insomnia Diazepam, Clobazam CYP2C19
Acid Related Disorders DexlansoprazoleEsomeprazole,
Lansoprazole, Omeprazole,
PantoprazoleRabeprazole
CYP2C19
Huntington Disease Tetrabenazine CYP2D6
Immunosupressants Tacrolimus CYP3A5
Muscle Relaxants Carisoprodol, Tizanidine CYP2C19, CYP1A2
Narcotic Addiction/Pain Methadone CYP2B6
Opioids Codeine, Fentanyl, Hydrocodone,
MorphineOxycodone, Tramadol
CYP2D6, OPRM1
Other Bupropion, Naltrexone COMT, OPRM1, ANKK1/DRD2
Other Analgesics Celecoxib, Flurbiprofen, Piroxicam CYP2C9
Urinary Incontinence Tolterodine CYP2D6

Cardiology Risk Factors

Condition Gene(s) Tested
Thrombosis Factor II, Factor V Leiden
Hyperhomocysteinemia MTHFR
Dyslipidemia APOE